The Clever Boys dominated the proceedings in the first half but failed to capitalise on any of their chances, with St Louisienne playing a very defensive first half. 8 Minutes before the half-time whistle Mhango scored with a great finish from a Mkhwanazi through ball.
The visitors headed into half time with a 1-0 lead over Saint Louisienne.
The second half resumed with Bidvest Wits applying pressure to the hosts, with Klate having the best chance when he saw his shot headed off the line.
61 minutes in, and the hosts equalized.
With only seconds remaining SS Saint Louisienne capitalised on a penalty, making the final score 2-1.
Although Bidvest Wits lost in Reunion, they returned to Johannesburg with a very important away goal.
The second leg will be played this Saturday at the Bidvest Stadium. Kickoff is set for 18h00.