The hosts were keen to bounce back after a disappointing loss against SuperSport United after their last outing in the Premiership and made their intentions clear when Gift Motupa opened the scoring in the third minute.
The visitors struggled to keep up with the pace and movement of Wits, who dominated the opening quarter of an hour, and threatened to score more than once through Haashim Domingo.
Mxolisi Macuphu had a great chance to double the hosts lead approaching the 20 minute mark, when the striker found himself through on goal, but his attempted chip ended up well wide of the target.
It didn’t take long for Macuphu to make amends. He finished cooly in the 28th minute to double The Clever Boys lead after a superb run by Deon Hotto in the build-up.
Gavin Hunt’s men continued to look for more goals as the half drew to an end but AmaZulu were able to hold on until the break, trailing by only two goals.
The second half saw Usuthu looking to grab an early goal, Thembela Sikhakhane coming close six minutes after the restart. His effort smashed into the crossbar from close range.
Just as the hosts were finding a rhythm, a killer blow was struck as Scottish striker Simon Murray netted his first for the club and a third on the night for Hunt’s charges.
The result sees Bidvest Wits open up a two point lead over Bloemfontein Celtic who did well to come from 2-0 down to Kaizer Chiefs to force a draw.
For their next fixture, Bidvest Wits travel to the Harry Gwala Stadium to face off against Maritzburg United, who have managed just one point from their first three games. Kick off is set for 15 September at 18:00.