The Clever Boys dominated proceedings from the get go with Sekese and company setting the pace throughout the fixture.
The first goal came from Mosiatlhaga, when he put his side in front from the spot after the referee penalised Aces for a handball in the box.
Bidvest Wits shot-stopper JP Van Der Merwe was good on the day, showing good concentration and lightning reflexes to deny several Black Aces efforts throughout the 90 minutes.
Mosiatlhaga doubled The Clever Boys’ lead shortly after halftime, with a composed finish after a super through ball from Thulani Ngcepe found the pacey mid-fielder in a yard of space.
Aces pulled a goal back through Judas Moseamedi on the hour mark, but were unable to break down a disciplined Bidvest Wits defence, who managed to hold on for their second win of the season.