Bidvest Wits will be away to Al Nasr in the CAF Confederation Cup Group C match on Sunday.
Kick-off is at 18h00 CAT.
The encounter is scheduled to be played at the Petro Sport Stadium in the capital city of Egypt, Cairo.
Libyan clubs play their home matches outside the country due to security concerns from the ongoing civil war.
Former South African champions Wits were held to a 0-0 draw by Libyan giants Al Nasr in Soweto last month.
Wits are sitting in the third spot on the group standings – two points behind second placed Djoliba AC.
Gift Motupa, who has been in good form for the Clever Boys, will be looking to help his side secure their maiden win in the group stage.
Meanwhile, Al Nasr are sitting on the fourth spot on the group standings – two points behind second Djoliba.
They will look to Khalid Almaryami, who is one of their key players having netted against Malian giants Djoliba last year.
Gabonese match official Pierre Atcho will be in charge of the match between Wits and Al Nasr.